Custom Peptides
Cayman Chemical Ravuconazole 10mg
An orally available azole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml); inhibits CYP isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes
Cayman Chemical TIn MSoporphyrIn IXCLOrId 10mg
A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia
Cayman Chemical 10 11dIhdro10hdrox Carb 10mg
An antiepileptic agent and active metabolite of oxcarbazepine; a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine
Cayman Chemical TetrahydroharmIn 10mg
A fluorescent indole alkaloid extracted from B. caapi that inhibits MAO-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 μM, respectively) compared to its companion harmala alkaloids: harmaline (IC50s = 2.5 nM and 25 μM, respectively) and harmine (IC50s = 2 nM and 20 μM, respectively)
Cayman Chemical 2-IodomelatonIn 10mg
A potent MT1 receptor agonist (Ki = 28 pM); 5-fold selective for MT1 over MT2; inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 (EC50 = 11 pM); has been used to characterize the role of MT1 in melatonin-mediated signaling
Cayman Chemical Ro 25-6981maleate 10mg
A potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50 = 9 nM); displays neuroprotectant effects in cortical neurons in vitro (IC50 = 0.04-0.4 μM)
Cayman Chemical ProstaglndIn F1a 10mg
PGF1α is the putative metabolite of DGLA via the COX pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Cayman Chemical IsoImperatrIn 10mg
A natural furanocoumarin that inhibits CYP1A activity, in particular blocking hepatic EROD activity; also induces the expression of GSTα by activating Nrf2
Cayman Chemical MS049hydrochlorIde 10mg
A selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM); reduces H3R2me2a in HEK293 cells (IC50 = 0.97 µM) and also, unexpectedly, to reduce H4R3me2a in HEK293 cells
Cayman Chemical notuberostemonIn 10mg
An alkaloid; inhibits LPS-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 100 µM; inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells at 50 µM; reduces the citric acid-induced cough reflex in conscious guinea pigs at 133 µmol/kg; inhibits pulmonary collagen deposition and fibrosis, as well as BALF monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis at 40 mg/kg
Cayman Chemical Foxy5trIfluoroACTAte salt 10mg
A Wnt5a peptide mimetic with anticancer activity; increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells from 1-1,000 µM; reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model at 2 mg/kg
Cayman Chemical DarunavIrethnolate 10mg
An HIV-1 protease inhibitor; active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) (CC50 = 74.4 μM); active against wild-type and multidrug-resistant clinical isolates of HIV-1 in PHA-PBMCs (IC50s = 3 and 3-29 nM, respectively); inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively)
Cayman Chemical AloIsIn RP106 10mg
An inhibitor of Cdk1, Cdk5, and GSK3 (IC50s = 0.70, 1.5, and 0.92 µM, respectively); a derivative of the aloisines A and B